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Sioux Falls is located at the junction of Interstate 29 (North-South) and Interstate 90 (East-West). Distances from other cities in the region are:
| City |
Distance (in miles)
to Sioux Falls |
| Chicago | 575 |
| Denver | 721 |
| Des Moines | 286 |
| Fargo-Moorhead | 243 |
| Mpls./St. Paul | 268 |
| Omaha | 183 |
| Rapid City | 346 |